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Introduction to Bioinformatics for Medical doctors and other Healthcare professionals
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Introduction
About you
Pre-course survey
Module 1: Introduction to Bioinformatics
Overview
Learning objectives
Introduction
Genes within Genomes
This content is graded
Overview of bioinformatics with respect to molecular biology and genetics concepts
Short problem 1.1
Navigating genomes
Learning activity 1.1
Quiz 1.1
Discussion
Searching Databases for Functional Information
This content is graded
Gathering information in medical genetic databases
Short problem 1.2
Gathering information in Generic Bioinformatics databases
Learning activity 1.2
Lesson 1.2 Quiz
Discussion
Exploring RNA and Protein products of a gene
This content is graded
Finding out about the level of expression of a gene
Short problem 1.3
Finding out about the protein
Learning activity 1.3
Quiz 1.3
Discussion
Healthy and Unhealthy proteins
This content is graded
Homology searches and multiple alignments in Biology
Short problem 1.4
Metabolic pathways and integrated cellular function
Learning activity 1.4
Quiz 1.4
Discussion
Practice Area
Instructions
Self assessment assignments 1
Open response assessments
Module 1 Discussion
Final Exams Module 1
This content is graded
Case studies - essay 1
Quiz I
Module 2: Computational Statistics for clinical doctors
Overview
Learning objectives
Introduction
Descriptive statistics
This content is graded
Type of variables and how to deal with them
Short problem 2.1
Introduction to R
Learning activity 2.1
Quiz 2.1
Discussion
Statistical inference
This content is graded
Overview of statistical significance
Short problem 2.2a
Learning activity 2.2a
Quiz 2.2a
Hypothesis testing in medical practice
Short problem 2.2b
Learning activity 2.2b
Quiz 2.2b
Discussion
Linear regression
This content is graded
Introduction to linear regression
Short problem 2.3
Linear regression models using R
Learning activity 2.3
Quiz 2.3
Discussion
Categorical Data
This content is graded
Introduction to Categorical Data Analysis
Short problem 2.4
Summary on the statistical inference interpretation
Learning activity 2.4
Quiz 2.4
Discussion
Practice Area
Self assessment assignments 2
Open Response Assessments 2
Final Exams - Module 2
This content is graded
Case study - essay 2
Quiz 2
Module 3: Personalised genomics in patient care
Overview
Learning objectives
Introduction
Inheritance Model of Diseases
This content is graded
Analysis of pedigrees. Mendelian models
Short problem 3.1
Other models of inheritance
Learning activity 3.1
Quiz 3.1
Discussion
Human Genetics sources of variability
This content is graded
Genetic variation
Short problem 3.2
Population variation or Disease causing variants
Learning activity 3.2
Quiz 3.2
Discussion
Diagnostic tools: How to select the correct test. Cytogenetics
This content is graded
Cytogenetics techniques and interpretation
Short Problem 3.3
Molecular cytogenetics techniques and interpretation
Learning activity 3.3
Quiz 3.3
Discussion
Diagnostic tools: How to select the correct test. Sequencing
This content is graded
Nucleotidic variants
Short problem 3.4
Interpretation of genomic analysis
Learning activity 3.4
Lesson 3.4 Quiz
Discussion
Practice Area
Self assessment practices 3
Open Response Assessments 3
Module 3 Discussion
Final Exams - Module 3
This content is graded
Final exam - Essay 3
Quiz III
Module 4: Quality improvement in Healthcare
Overview
Learning objectives
Introduction
Risk assessment
This content is graded
Genetic risk assessment
Short Problem 4.1
Genetic risk prediction in complex disorders
Learning activity 4.1
Quiz 4.1
Discussion
Ethical and Communication skills
Ethical and communication skills
Learning Activity 4.2
Discussion
Practice Area
Self assessment practices 4
Open Response Assessments 4
Final Exams - Module 4
This content is graded
Final exam - Essay 4
Quiz IV
Post-course survey
Post-course survey
Post-course survey
Webinars
Webinar 1 - Systemic interpretation of data from different –omic layers and derivation of diagnostic, personalized signatures of molecular biomarkers, assisting medical decision
Handouts
Recording
Webinar 2 - How to evaluate diagnostic information?
Recording
Handouts
Webinar 3 - Commercial personalized genomics services in patient care
Recording
Handouts
Open bioinformatic tools
Introduction to Galaxy
Galaxy tutorial