BioS: BioS-ENx Introduction to Bioinformatics for Medical doctors and other Healthcare professionals

Learning objectives

Introduction

Overview of bioinformatics with respect to molecular biology and genetics concepts

Short problem 1.1

Navigating genomes

Learning activity 1.1

Quiz 1.1

Discussion

Gathering information in medical genetic databases

Short problem 1.2

Gathering information in Generic Bioinformatics databases

Learning activity 1.2

Lesson 1.2 Quiz

Discussion

Finding out about the level of expression of a gene

Short problem 1.3

Finding out about the protein

Learning activity 1.3

Quiz 1.3

Discussion

Homology searches and multiple alignments in Biology

Short problem 1.4

Metabolic pathways and integrated cellular function

Learning activity 1.4

Quiz 1.4

Discussion

Instructions

Self assessment assignments 1

Open response assessments

Module 1 Discussion

Case studies - essay 1

Quiz I

Learning objectives

Introduction

Type of variables and how to deal with them

Short problem 2.1

Introduction to R

Learning activity 2.1

Quiz 2.1

Discussion

Overview of statistical significance

Short problem 2.2a

Learning activity 2.2a

Quiz 2.2a

Hypothesis testing in medical practice

Short problem 2.2b

Learning activity 2.2b

Quiz 2.2b

Discussion

Introduction to linear regression

Short problem 2.3

Linear regression models using R

Learning activity 2.3

Quiz 2.3

Discussion

Introduction to Categorical Data Analysis

Short problem 2.4

Summary on the statistical inference interpretation

Learning activity 2.4

Quiz 2.4

Discussion

Self assessment assignments 2

Open Response Assessments 2

Case study - essay 2

Quiz 2

Learning objectives

Introduction

Analysis of pedigrees. Mendelian models

Short problem 3.1

Other models of inheritance

Learning activity 3.1

Quiz 3.1

Discussion

Genetic variation

Short problem 3.2

Population variation or Disease causing variants

Learning activity 3.2

Quiz 3.2

Discussion

Cytogenetics techniques and interpretation

Short Problem 3.3

Molecular cytogenetics techniques and interpretation

Learning activity 3.3

Quiz 3.3

Discussion

Nucleotidic variants

Short problem 3.4

Interpretation of genomic analysis

Learning activity 3.4

Lesson 3.4 Quiz

Discussion

Self assessment practices 3

Open Response Assessments 3

Module 3 Discussion

Final exam - Essay 3

Quiz III

Learning objectives

Introduction

Genetic risk assessment

Short Problem 4.1

Genetic risk prediction in complex disorders

Learning activity 4.1

Quiz 4.1

Discussion

Ethical and communication skills

Learning Activity 4.2

Discussion

Self assessment practices 4

Open Response Assessments 4

Final exam - Essay 4

Quiz IV

Post-course survey

Handouts

Recording

Recording

Handouts

Recording

Handouts

Galaxy tutorial